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Registro Completo |
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Biblioteca(s): |
Embrapa Agroenergia. |
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Data corrente: |
23/11/2022 |
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Data da última atualização: |
23/11/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CARNEIRO, C. V. G. C.; SERRA, L. A.; PACHECO, T. F.; FERREIRA, L. M. M.; DUARTE, L. T.; FREITAS, M. N. de M.; TRICHEZ, D.; ALMEIDA, J. R. M. de. |
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Afiliação: |
CLARA VIDA GALRÃO CORRÊA CARNEIRO, UNB/CNPAE; LUANA ASSIS SERRA, UNB/CNPAE; THALYTA FRAGA PACHECO, CNPAE; LETÍCIA MARIA MALLMANN FERREIRA, UNB/CNPAE; LIVIA TEIXEIRA DUARTE BRANDAO, CNPAE; MARIANA NOGUEIRA DE MOURA FREITAS, UNB/CNPAE; DÉBORA TRICHEZ, UNB/CNPAE; JOAO RICARDO MOREIRA DE ALMEIDA, CNPAE. |
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Título: |
Advances in Komagataella phaffii Engineering for the Production of Renewable Chemicals and Proteins |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Fermentation, v. 8, n. 575, p. 2-37, 2022. |
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DOI: |
https://doi.org/10.3390/fermentation8110575 |
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Idioma: |
Inglês |
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Conteúdo: |
The need for a more sustainable society has prompted the development of bio-based processes to produce fuels, chemicals, and materials in substitution for fossil-based ones. In this context, microorganisms have been employed to convert renewable carbon sources into various products. The methylotrophic yeast Komagataella phaffii has been extensively used in the production of heterologous proteins. More recently, it has been explored as a host organism to produce various chemicals through new metabolic engineering and synthetic biology tools. This review first summarizes Komagataella taxonomy and diversity and then highlights the recent approaches in cell engineering to produce renewable chemicals and proteins. Finally, strategies to optimize and develop new fermentative processes using K. phaffii as a cell factory are presented and discussed. The yeast K. phaffii shows an outstanding performance for renewable chemicals and protein production due to its ability to metabolize different carbon sources and the availability of engineering tools. Indeed, it has been employed in producing alcohols, carboxylic acids, proteins, and other compounds using different carbon sources, including glycerol, glucose, xylose, methanol, and even CO2. |
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Palavras-Chave: |
Komagataella phaffii. |
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Thesagro: |
Biologia Vegetal. |
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Thesaurus Nal: |
Bioengineering; Pichia pastoris. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1148607/1/Advances-in-komagataella-phaffii.pdf
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Marc: |
LEADER 02069naa a2200265 a 4500
001 2148607
005 2022-11-23
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3390/fermentation8110575$2DOI
100 1 $aCARNEIRO, C. V. G. C.
245 $aAdvances in Komagataella phaffii Engineering for the Production of Renewable Chemicals and Proteins$h[electronic resource]
260 $c2022
520 $aThe need for a more sustainable society has prompted the development of bio-based processes to produce fuels, chemicals, and materials in substitution for fossil-based ones. In this context, microorganisms have been employed to convert renewable carbon sources into various products. The methylotrophic yeast Komagataella phaffii has been extensively used in the production of heterologous proteins. More recently, it has been explored as a host organism to produce various chemicals through new metabolic engineering and synthetic biology tools. This review first summarizes Komagataella taxonomy and diversity and then highlights the recent approaches in cell engineering to produce renewable chemicals and proteins. Finally, strategies to optimize and develop new fermentative processes using K. phaffii as a cell factory are presented and discussed. The yeast K. phaffii shows an outstanding performance for renewable chemicals and protein production due to its ability to metabolize different carbon sources and the availability of engineering tools. Indeed, it has been employed in producing alcohols, carboxylic acids, proteins, and other compounds using different carbon sources, including glycerol, glucose, xylose, methanol, and even CO2.
650 $aBioengineering
650 $aPichia pastoris
650 $aBiologia Vegetal
653 $aKomagataella phaffii
700 1 $aSERRA, L. A.
700 1 $aPACHECO, T. F.
700 1 $aFERREIRA, L. M. M.
700 1 $aDUARTE, L. T.
700 1 $aFREITAS, M. N. de M.
700 1 $aTRICHEZ, D.
700 1 $aALMEIDA, J. R. M. de
773 $tFermentation$gv. 8, n. 575, p. 2-37, 2022.
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Registro original: |
Embrapa Agroenergia (CNPAE) |
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| Registros recuperados : 13 | |
| 1. |  | TRICHEZ, D.; BERGMANN, J. C.; GARCIA, L. C.; JUNGMANN, L. How many bioethanol generations can we have? In: TREICHEL, H.; ALVES JÚNIOR, S. L.; FONGARO, G.; MÜLLER, C. Ethanol as a green alternative fuel: insight and perspectives. Hauppauge, NY: Nova Science Publishers, 2019. cap. 2. p . 21-57.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Agroenergia. |
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| 3. | | TRICHEZ, D.; PORTO, B. N.; PACHECO, T. F.; GONCALVES, S. B.; FORMIGHIERI, E. F.; ALMEIDA, J. R. M. de. Physiological and genetic characterization of new Brazilian yeasts for fuels and chemicals production from renewable resources. In: SYMPOSIUM ON THE CHEMISTRY, BIOLOGY AND APPLICATION OF LYTIC POLYSACCHARIDE MONOOXYGENASES, 2016, Copenhagen, Denmark. [Proceedings ...]. Hellerup: Novo Nordisk Fonden, 2016. Não paginado. Resumo nº S10B-1 (P-200).| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroenergia. |
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| 4. | | MORAIS JÚNIOR, W. G. de; PACHECO, T. F.; TRICHEZ, D.; ALMEIDA, J. R. M. de; GONCALVES, S. B. Seleção e identificação de nova linhagem de levedura não-Saccharomyces tolerante ao hidrolisado lignocelulósico de cana-de-açúcar para produção de xilitol. In: ENCONTRO DE PESQUISA E INOVAÇÃO DA EMBRAPA AGROENERGIA, 5., 2018, Brasília, DF. Anais ... Brasília, DF: Embrapa Agroenergia, 2018. p. 27.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroenergia. |
|  |
| 5. | | BERGMANN, J. C.; TRICHEZ, D.; SALLET, L. P.; SILVA, F. C. de P.; ALMEIDA, J. R. M. de. Technological advancements in 1G ethanol production and recovery of by-products based on the biorefinery concept. In: CHANDEL, A. K.; SILVEIRA, M. H. L. Advances in sugarcane biorefinery: technologies, commercialization, policy issues and paradigm shift for bioethanol and by-products. Amsterdam: Elsevier, 2018. P. 73-95. Capítulo 4.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Agroenergia. |
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| 6. | | TRICHEZ, D.; STEINDORFF, A. S.; SOARES, C. E. V. F.; FORMIGHIERI, E. F.; ALMEIDA, J. R. M. de. Xylitol production: physiological and genetic characterization of new yeast strains. In: SYMPOSIUM ON BIOTECHNOLOGY FOR FUELS AND CHEMICALS, 2017, 39., San Francisco, US. [Proceedings ...]. Fairfax: Society for Industrial Microbiology and Biotechnology, 2017. Não paginado.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroenergia. |
|  |
| 8. | | TRICHEZ, D.; CARNEIRO, C. V. G. C.; SOARES, C. E. V. F.; STEINDORFF, A. S.; FORMIGHIERI, E. F.; ALMEIDA, J. R. M. de. Biodiversity bioprospecting for xylitol production: selection, physiological and genetic characterization of new yeast strains. In: INTERNATIONAL SPECIALISED SYMPOSIUM ON YEAST - ISSY, 33., 2017, Cork, Ireland. [Proceedings ...]. [S.l]: International Commission on Yeasts, 2017. Não paginado.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroenergia. |
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| 9. | | TRICHEZ, D.; STEINDORFF, A. S.; MORAIS JÚNIOR, W. G. de; VILELA, N.; BERGMANN, J. C.; FORMIGHIERI, E. F.; GONCALVES, S. B.; ALMEIDA, J. R. M. de. Identification of traits to improve co-assimilation of glucose and xylose by adaptive evolution of Spathaspora passalidarum and Scheffersomyces stipitis yeasts. Applied Microbiology and Biotechnology, n. 107, p. 1143?1157, Feb. 2023.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Agroenergia. |
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| 11. | | CARNEIRO, C. V. G. C.; SERRA, L. A.; PACHECO, T. F.; FERREIRA, L. M. M.; DUARTE, L. T.; FREITAS, M. N. de M.; TRICHEZ, D.; ALMEIDA, J. R. M. de. Advances in Komagataella phaffii Engineering for the Production of Renewable Chemicals and Proteins Fermentation, v. 8, n. 575, p. 2-37, 2022.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Agroenergia. |
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| 12. | | TORRES, N. A. M.; ANDRADE, T. M. G. de; SOUSA, T. D. de; DUARTE-BRANDÃO, L. T.; NAKAI, D. K.; TRICHEZ, D.; CARNEIRO, C. V. G. C.; REIS, V. C. B.; ALMEIDA, J. R. M. de. Engenharia metabólica para a produção de etileno glicol por Komagataella phaffii a partir de hidrolisados de biomassa. In: ENCONTRO DE PESQUISA E INOVAÇÃO DA EMBRAPA AGROENERGIA, 7., 2023, Brasília, DF. Anais... Brasília, DF : Embrapa, 2023. p. 24.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Agroenergia. |
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| 13. | | RAMOS, T. G. S.; JUSTEN, F.; CARNEIRO, C. V. G. C.; HONORATO, V. M.; FRANCO, P. F.; VIEIRA, F. S.; TRICHEZ, D.; RODRIGUES, C. M.; ALMEIDA, J. R. M. de. Xylonic acid production by recombinant Komagataella phaffii strains engineered with newly identified xylose dehydrogenases. Bioresource Technology Reports, v. 16, 100825, Dec. 2021. 6 p. PDF: il.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 4 |
| Biblioteca(s): Embrapa Agroenergia. |
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| Registros recuperados : 13 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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